Nigel de Jong starts on the bench as City have gone with Yaya Toure, Gareth Barry and the in-form James Milner in the middle. It's a gutsy move by Mancini as the control of the midfield has always been the key to the Manchester derby the past few years.
As expected Gael Clichy gets the nod at left back in the preferred City defensive line and Aguero and Balotelli will start up front. Sir Alex Ferguson has also pulled a couple of surprises. Jonny Evans in for Nemanja Vidic is potentially huge because while Evans has good recovery instincts he can be turned fairly easily. Phil Jones also does not start with Chris Smalling taking his place.
The biggest concern for City is if Rooney drifts back to make it a five man midfield before then working with Wellbeck up front.
Some fascinating player choices for both sides. I think I would have taken Dzeko over Balotelli in such a formation. I'll be curious to see if City are playing a diamond or have Balotelli and Silva out on the wings to help with Nani and Young.
City: Hart, Richards, Kompany, Lescott, Clichy, Toure, Barry, Milner, Silva, Balotelli, Aguero. Subs: Pantilimon, Zabaleta, Nasri, Toure, De Jong, Kolarov, Dzeko.
United: De Gea, Smalling, Ferdinand, Evans, Evra, Nani, Fletcher, Anderson, Young, Rooney, Welbeck. Subs: Lindegaard, Hernandez, Da Silva, Valencia, Jones, Berbatov, Park.