Kalou gave Chelsea the lead after only one minute and thirteen seconds. An early Chelsea corner was flicked on and the ball ended up at Kalou's feet, who put the Blues ahead from a couple of yards out.
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The home fans did not have to wait too long for their second as Malouda doubled their lead after just 12 minutes.
Every time Chelsea had the ball they looked like scoring and their second came from a slick passing move as Essien broke then fed Drogba who played in Malouda for an easy finish.
Playing Alex Baptiste in a holding midfield role seemed to have little effect on the probing Chelsea front three, but going forward he forced Petr Cech into making his finest save of the first half from a long range effort.
Shortly after the game was over as Drogba's fortuitous strike from outside the box took a huge deflection past Matt Gilks to put the champions three nil up after only half an hour.
Four minutes before the break Kalou sprung the offside trap to play in Malouda to make it four and that is how it stayed until half time.
Chelsea's front trio of Drogba, Malouda, and Kalou ran rings around the Blackpool defence and all three scored in the first forty-five minutes.
The second half was all about playing with pride and trying to better the six nil away loss to Arsenal.
Blackpool fared much better in the second forty-five holding Chelsea to a goalless draw and the away side could have even grabbed a consolation goal.
DJ Campbell had an attempt cleared off the line, Gary Taylor-Fletcher forced Cech into a scrambling save and Marlon Harewood smashed the ball into the near post side netting from close out.
Some Blackpool fans thought Harewood's strike had gone in as the ball rolled across the netting behind the goal but it was not to be.
Once again the Tangerine army were in full voice and out sang the Chelsea fans from the first whistle to the last.
On reflection a four nil away loss to the champions is not so bad considering Chelsea had averaged over four goals a game in their opening four Premier League fixtures and the Seasiders held the champions for the whole of the second half.
These are not the games that will decide Blackpool's Football League status at the end of the season, and despite the loss, Ollie's team still find themselves with seven points having only played one home game and getting two of the toughest fixtures out of the way; away to Arsenal and Chelsea.
A tasty Lancashire derby awaits next weekend as Rovers return to Bloomfield Road. Once again I predict goals and a more positive result for the Tangerine Army.
FT: Chelsea 4 - 0 Blackpool
Malouda 12, 41
Chelsea: Cech, Ferreira, Ivanovic, Alex (>71), Cole, Essien, Ramires (>74), Mikel (>77), Malouda, Drogba, Kalou. Subs: Turnbull, Benayoun (<77), Zhirkov (<74), Stirridge, Anelka, Bruma (<71), Kakuta
Blackpool: Gilks, Eardley (>46), Keinan, Evatt, Crainey, Baptiste, Adam, Vaughan, Grandin (>61), Varney (>61), Campbell. Subs: Halstead, Southern, Harewood (<61), Ormerod (<61), Taylor-Fletcher (<46), Carney, Cathcart
Venue: Stamford Bridge
Referee: Mark Clattenburg